Condition: Gastric (Stomach) Cancer · Sponsor: West China Hospital
This study investigates the efficacy and safety of XELOX chemotherapy combined with sintilimab and hyperbaric oxygen therapy (HBOT) as a first-line treatment for patients with Advanced or Metastatic gastric and gastroesophageal junction adenocarcinoma. The trial comprises two phases: a phase Ib study to determine the optimal HBOT regimen and assess safety and tolerability, followed by a phase II study to evaluate the overall response rate (ORR). Secondary outcomes include progression-free survival (PFS), disease control rate (DCR), 2-year disease-free survival (DFS), 2-year overall survival (OS), safety, and quality of life. This study aims to provide a novel approach for enhancing therapeutic efficacy and improving patient outcomes by leveraging HBOT to address tumor hypoxia and augment the effects of chemotherapy and immune checkpoint inhibitors.
This description comes directly from the study's public registry record.
Ming Liu, M.D · +8618980606324 · mingliu721@aliyun.com
Cheng Huang, M.D · +8618980603143
Always discuss trial participation with your own doctor first.
| West China Hospital of Sichuan University | Chengdu, Sichuan, China | Recruiting |
| West China Hospital, Sichuan University | Chengdu, Sichuan, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06742411