Condition: Primary Aldosteronism · Hypertension · Sponsor: Medical University of Gdansk
The goal of this observational study is to learn whether screening for primary aldosteronism can be improved among patients on chronic blood pressure-lowering medications by ordering intake of 1 mg of dexamethasone prior to hormonal examinations. Primary aldosteronism is a condition, in which an adrenal gland steroid aldosterone is released in excessive amounts; it commonly causes hypertension but requires specific therapy different from usually prescribed in other forms of hypertension. Dexamethasone is a synthetic steroid used for both therapeutic and diagnostic purposes. A single 1 mg dexamethasone dose taken at 11 p.m. in order to measure hormone concentrations the following morning (so called overnight 1-mg dexamethasone test) is a commonly applied test in the work-up of adrenal disorders. The main question the project aims to answer is: Can screening for primary aldosteronism be improved among patients receiving blood pressure-lowering medications with overnight 1-mg dexamethasone intake? Participants will undergo changes in their chronic medication to be able to definitely rule out or confirm primary aldosteronism in blood hormonal examinations. These modifications and modifications are not part of the research project. For this project participants will be asked to * undergo the 1-mg dexamethasone test one to three times in order to compare hormonal concentrations before and after it, * collect urine for 24 hours to determine aldosterone in the urine sample aft…
This description comes directly from the study's public registry record.
Piotr Kmiec, M.D., Ph.D. · 0048 585844809 · piotrkmiec@gumed.edu.pl
Renata Swiatkowska-Stodulska, Professor, MD, Ph.D. · 0049 585844800 · rensto@gumed.edu.pl
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| Department of Endocrinology and Internal Medicine, University Clinical Center, Medical University of Gdansk | Gdansk, Pomeranian Voivodeship, Poland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06740838