Condition: Primary Progressive Aphasia(PPA) · Sponsor: Istituti Clinici Scientifici Maugeri SpA
Primary progressive aphasia (PPA) is an umbrella term used to refer to several clinical variants that manifest as an insidious deterioration of speech/language skills, usually due to frontotemporal lobar degeneration and/or Alzheimer's disease. Consensus criteria have been proposed by an international community regarding the sub-classification of PPA into three variants: (1) semantic variant PPA, characterized by impaired confrontation naming and single-word comprehension; (2) logopenic variant PPA), characterised by word-finding difficulties and sentence repetition deficits; and (3) non-fluent variant, characterised by agrammatism with or without apraxia of speech. Speech and language therapists (SLTs) play a crucial role in the diagnostic process and in setting a therapeutic path along with monitoring the evolution of the clinical picture. Despite growing evidence supporting the benefits of speech-language intervention, the frequency with which individuals with PPA are referred for speech and language services, is suboptimal likely due to skepticism regarding the value of speech and language therapy in the context of neurodegeneration, the scarcity of SLTs with expertise in the treatment of PPA, the lack of awareness regarding the role of the SLT amongst referrers, and the geographical barriers that impede access to in-person speech and language services. In Italy, patients with PPA are rarely offered treatment options due to a lack of understanding of the disorder on the …
This description comes directly from the study's public registry record.
Petronilla Battista, PhD · +390807814331 · petronilla.battista@gbhi.org
Christian Lunetta, MD · +39 02 5072 5266 · christian.lunetta@icsmaugeri.it
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| Istituti Clinici Scientifici Maugeri IRCCS | Bari, Italy | Recruiting |
| IRCCS Ospedale San Raffaele | Milan, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06739967