← Eichor
Study identifier: NCT06735820 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST

Condition: Malignant Peripheral Nerve Sheath Tumor (MPNST) · Neurofibromatosis 1 (NF1) · Atypical Neurofibroma  ·  Sponsor: AeRang Kim

PhasePhase 1/Phase 2
Planned participants45
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase 0/1/2, multi-site study to evaluate the MEK inhibitor Selumetinib with the MDM2 Inhibitor APG-115 in patients with Neurofibromatosis Type 1 and pre-malignant and malignant peripheral nerve sheath tumors

This description comes directly from the study's public registry record.

Talk to the study team

Vidya Chenji  ·  202-476-3745  ·  nchenji@childrensnational.org

Always discuss trial participation with your own doctor first.

Locations (2)

Children's National HospitalWashington D.C., District of Columbia, United StatesRecruiting
UT Southwestern Medical CenterDallas, Texas, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06735820