Condition: Hepatocellular Carcinoma (HCC) · Intrahepatic Cholangiocarcinoma (Icc) · Neuroendocrine Tumors · Sponsor: Nantes University Hospital
Precision medicine represents a major goal in oncology. It has its underpinning in the identification of biomarkers with diagnostic, prognostic, or predictive values. Gastro-entero-pancreatic neuroendocrine neoplasia (GEP-NENs) are rare tumors, but their frequency is increasing. In this context, the tumor expression of carbonic anhydrase IX (CAIX), complemented by a restricted profile in normal tissues, provides an opportunity for therapeutic targeting and precision medicine. Indeed, radiolabeling the anti-CAIX monoclonal antibody girentuximab with Zirconium 89 has shown promise as a novel positron emission tomography (PET) tracer and labeling with 177 Lutetium promise as a therapeutic agent in clear cell renal cell carcinoma (ccRCC) in the context of a theranostic approach. The purpose of this study is to evaluate the use of 89Zr-labeled girentuximab (89Zr-TLX250) as a novel, carbonic anhydrase IX (CAIX) targeted PET/CT tracer for the imaging of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms, Hepatocellular Carcinoma or IntraHepatic Cholangiocarcinoma.
This description comes directly from the study's public registry record.
Clément BAILLY · +33240084136 · clement.bailly@chu-nantes.fr
Astrid GARREAU · +33253482840 · astrid.garreau@chu-nantes.fr
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| CHU de Nantes | Nantes, France | Recruiting |
| AP-HP - Site de Beaujon | Paris, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06735560