Condition: Ovarian Cancer · Fallopian Tube Cancer · Peritoneal Cancer · Sponsor: Qilu Hospital of Shandong University
This study is a randomized, open-label, multi-cohort, multicenter clinical trial, aimed at evaluating the efficacy and safety of Fluzoparib monotherapy, Fluzoparib in combination with Bevacizumab, and standard chemotherapy (Paclitaxel plus Carboplatin) as neoadjuvant treatments in newly diagnosed, germline BRCA1/2-mutated epithelial ovarian cancer patients (FIGO stage III/IV). The study also aims to assess the efficacy and safety of Fluzoparib as maintenance therapy following surgery and chemotherapy. The primary endpoint of the study is the objective response rate (ORR) for neoadjuvant therapy, as assessed by the investigator using RECIST v1.1 criteria. Secondary endpoints include R0 resection rate, overall survival (OS), and progression-free survival (PFS). The study will also evaluate the safety, tolerability, and patient-reported outcomes (EQ-5D-5L) across the three treatment cohorts.
This description comes directly from the study's public registry record.
Hualei Bu · (+86)0531-82165881 · buhualei@email.sdu.edu.cn
Always discuss trial participation with your own doctor first.
| Qilu Hospital of Shandong University | Jinan, Shandong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06735326