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Study identifier: NCT06734533 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Anlotinib-based Combination Therapy in Patients with Hormone Receptor-positive(HR+) Metastatic Breast Cancer(MBC) .

Condition: HR+ Breast Cancer  ·  Sponsor: Hunan Cancer Hospital

PhaseN/A
Planned participants80
Who can joinFemale, 18 Years to 75 Years
Healthy volunteersNo

About this study

Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors combined with hormonal therapy are the current standard frontline treatment for patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER-2)-negative metastatic breast cancer (MBC). However, the optimal treatment after progression on CDK4/6 inhibitors remains unknown. Anlotinib is an oral multi-target tyrosine kinase inhibitor (TKI) that strongly inhibits VEGFR, PDGFR, FGFR, and c-kit. This study aimed to evaluate the safety and efficacy of anlotinib-based combination therapy in patients with HR+ MBC previously treated with a CDK4/6 inhibitor.

This description comes directly from the study's public registry record.

Talk to the study team

Quchang Ouyang  ·  15676789890  ·  tgzybc@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Hunan Provincial Tumor HospitalChangsha, Hunan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06734533