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Study identifier: NCT06734481 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion

Condition: Complicated Pleural Effusion/ Empyema  ·  Sponsor: First Affiliated Hospital of Ningbo University

PhaseNA
Planned participants260
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to evaluate the safety and efficacy of sodium bicarbonate pleural lavage in treating complex pleural effusion in adult. The main questions it aims to answer are: Will sodium bicarbonate pleural lavage reduce the failure rate of medical treatment (referral rate for surgery) for complicated pleural effusion? Can sodium bicarbonate pleural lavage accelerating the rehabilitation of patients with complicated pleural effusion? Will sodium bicarbonate pleural lavage improve the prognosis of patients with complicated pleural effusion? Participants will will undergo catheter placement for continuous drainage of pleural effusion. Once at least 200 mL of pleural effusion has been drained: Group A: Participants will receive a daily intrapleural injection of 200 mL of saline in 7 days; Group B: Participants will receive a daily intrapleural injection of 200 mL of 2.5% sodium bicarbonate in 7 days.

This description comes directly from the study's public registry record.

Talk to the study team

Chao Cao, Doctor  ·  +86-0574-87089878  ·  caocdoctor@163.com

Fang Liu  ·  +86-0574-87089878  ·  liufangzju2010@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

the First Affiliated Hospital of Ningbo UniversityNingbo, Zhejiang, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06734481