Condition: Stomach Neoplasm · Gastric (Stomach) Cancer · Sponsor: Asan Medical Center
Claudin 18.2 is a promising therapeutic target overexpressed on the surface of gastric cancer cells. The addition of zolbetuximab, the monoclonal antibody targeting Claudin 18.2 to chemotherapy in two recent Phase 3 studies prolonged survival outcomes, indicating that Claudin 18.2 is a valid target in gastric cancer. Asan Medical Center researchers conducted a study on Claudin 18.2 expression in patients with operable gastric cancer and defined moderate to strong claudin expression in more than 75% of tumor cells as Claudin 18.2 overexpression, which was observed in 46.5% of patients with stage I-III tumors. This suggests that zolbetuximab-based treatment may be possible in patients with LAGC. Therefore, The investigator designed a prospective, multicenter, open-label, Phase Ib/II study to determine the efficacy and safety of zolbetuximab/DOS as neoadjuvant chemotherapy in patients with LAGC.
This description comes directly from the study's public registry record.
Min-Hee Ryu, MD,PhD · 82-2-3010-5935 · miniryu@amc.seoul.kr
Hyung-Don Kim, MD,PhD · 82-2-3010-5935 · kimhdmd@amc.seoul.kr
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| Asan Medical Center | Seoul, South Korea | Recruiting |
| Asan Medical Center | Seoul, South Korea | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06732856