Condition: OVARIAN STIMULATION · Telomere Length · Telomere Length, Mean Leukocyte · Sponsor: ART Fertility Clinics LLC
Gonal-F® (follitropin alfa) is a recombinant FSH without LH activity, while Menopur® contains both LH and hCG. The MEGASET trial compared Menopur® and Gonal-F® in GnRH antagonist cycles with SET, showing similar efficacy. A subsequent study (MEGASET-HR) in high responders found ongoing pregnancy rates of 35.5% for Menopur® and 30.7% for Gonal-F®, with a lower early pregnancy loss for Menopur® (14.5% vs 25.5%). Telomere length (TL) in oocyte cumulus cells (CC) correlates with oocyte quality and embryo outcomes. This study aims to assess whether stimulation type (hMG vs. Gonal-F) affects TL in CC and subsequent blastocyst development. A randomized, open-label, cross-over study in normo-responders will analyze telomere length, embryo quality, and hormonal markers.
This description comes directly from the study's public registry record.
Daniela Nogueira · 971504374961 · daniela.nogueira@artfertilityclinics.com
Jonalyn DV Edades · +971526408688 · jonalyn.ededas@artfertilityclinics.com
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| ART Fertility Clinics | Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06732843