Condition: Non-small Cell Lung Cancer · Sponsor: Merck Sharp & Dohme LLC
Researchers are investigating new treatments for untreated advanced non-small cell lung cancer (NSCLC), which is the most common form of lung cancer and lung cancer that has spread beyond surgical removal. Standard treatments include immunotherapy, such as pembrolizumab, and chemotherapy. This study aims to determine the effectiveness of adding other treatments, including the human epidermal growth factor receptor 3-directed antibody-drug conjugate (HER3-DXd) patritumab deruxtecan, to pembrolizumab, with or without chemotherapy. The primary goals are to assess safety and efficacy of the treatments.
This description comes directly from the study's public registry record.
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| University of Kentucky ( Site 0019) | Lexington, Kentucky, United States | Recruiting |
| MedStar Franklin Square Medical Center ( Site 0033) | Baltimore, Maryland, United States | Recruiting |
| Sanford Fargo Medical Center ( Site 0039) | Fargo, North Dakota, United States | Recruiting |
| Abramson Cancer Center ( Site 0010) | Philadelphia, Pennsylvania, United States | Recruiting |
| Sanford Cancer Center ( Site 0038) | Sioux Falls, South Dakota, United States | Recruiting |
| Centro de Estudios Clínicos SAGA ( Site 0162) | Santiago, Region M. de Santiago, Chile | Recruiting |
| FALP ( Site 0161) | Santiago, Region M. de Santiago, Chile | Recruiting |
| Bradfordhill ( Site 0160) | Santiago, Region M. de Santiago, Chile | Recruiting |
| THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 0204) | Athens, Attica, Greece | Recruiting |
| European Interbalkan Medical Center-Oncology Department ( Site 0205) | Thessaloniki, Greece | Recruiting |
| Petz Aladar Egyetemi Oktato Korhaz ( Site 0062) | Győr, Győr-Moson-Sopron, Hungary | Recruiting |
| Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet ( Site 0061) | Szolnok, Jász-Nagykun-Szolnok, Hungary | Recruiting |
+ 29 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06731907