Condition: Gastroschisis · Congenital Diaphragmatic Hernia · Duodenal Atresia · Sponsor: Liverpool Women's NHS Foundation Trust
The SuNDiAL study will measure levels of two naturally occurring amino acids: Arginine and Asymmetric Dimethylarginine (ADMA) in neonates undergoing abdominal surgery in the first 5 days of life due to congenital abdominal malformations as the participants recover from surgery. The investigators hypothesise that the relationship between Arginine and ADMA may be useful in predicting recovery and complications in babies who have had abdominal surgery due to previous research published in adult patients undergoing abdominal surgery. If this relationship is found to be useful there may be options for developing treatments (such as arginine supplementation) in the future to improve recovery and reduce complications in neonates undergoing abdominal surgery. Neonates born after 35 weeks gestation who have a congenital abdominal malformation who require abdominal surgery in the first 5 days will be eligible to participate in the SuNDiAL study. Arginine and ADMA will be measured from blood samples that are left over from the participant's blood tests that are taken as part of their routine clinical care. The investigators will measure Arginine and ADMA preoperatively and at least 10 points in the 30 days following their surgery, or until the participant fully recovers from surgery (which ever comes first). There is no intervention in the SuNDiAL study, and there will be no extra blood or blood samples taken. Serums samples that are left over from the babies routine clinical blood …
This description comes directly from the study's public registry record.
Colin Morgan · 0151 7024382 · colin.morgan@lwh.nhs.uk
Joshua Stead · 0151 7024382 · joshua.stead@nhs.net
Always discuss trial participation with your own doctor first.
| Alder Hey Childrens Hospital NSH Foundation Trust | Liverpool, Merseyside, United Kingdom | Recruiting |
| Liverpool Womens Hospital NHS Foundation Trust | Liverpool, Merseyside, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06731855