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Study identifier: NCT06730373 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

First-line Treatment With RC48 Plus Sintilimab and S-1 in Advanced Gastric Cancer (RCTS2)

Condition: HER2-positive Gastric Cancer · Metastatic Gastric Cancer · Unresectable Gastric Carcinoma  ·  Sponsor: Qilu Hospital of Shandong University

PhasePhase 2
Planned participants110
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a Phase II, randomized, multicenter, open-label clinical trial designed to compare Disitamab Vedotin plus Sintilimab and S-1 with Trastuzumab plus chemotherapy ± Sintilimab for first-line treatment of HER2-Positive advanced gastric or gastroesophageal junction adenocarcinoma.

This description comes directly from the study's public registry record.

Talk to the study team

Lian Liu, MD  ·  0531-82169851  ·  tounao@126.com

Song Li, MD  ·  0531-82169851

Always discuss trial participation with your own doctor first.

Locations (20)

The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, Henan, ChinaRecruiting
Binzhou Medical University HospitalBinzhou, Shandong, ChinaNot Yet Recruiting
Shengli Oilfield Central HospitalDongying, Shandong, ChinaRecruiting
Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan, Shandong, ChinaRecruiting
Shandong Provincial Third HospitalJinan, Shandong, ChinaRecruiting
Shandong Univerisity Qilu HospitalJinan, Shandong, ChinaRecruiting
Jinan Third People's HospitalJinan, Shandong, ChinaRecruiting
Affiliated Hospital of Jining Medical CollegeJining, Shandong, ChinaRecruiting
Liaocheng People's HospitalLiaocheng, Shandong, ChinaRecruiting
Linyi Cancer HospitalLinyi, Shandong, ChinaRecruiting
Qilu Hospital of Shandong University(Qingdao)Qingdao, Shandong, ChinaRecruiting
The Affiliated Hospital of Qingdao UniversityQingdao, Shandong, ChinaNot Yet Recruiting

+ 8 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06730373