Condition: Pulmonary Tuberculosis · Sponsor: Kaohsiung Veterans General Hospital.
Tuberculosis remains an important global health problem, and the world is currently not on track to end the TB epidemic by 2030. With the concerted efforts of the government and medical community, the incidence of TB in Taiwan has gradually decreased, however, Taiwan remains an endemic area for TB. The development of efficacious, safe, and shorter treatment regimens could significantly improve treatment completion rate and reduce transmission of TB. The current treatment guidelines for drug-susceptible TB from the World Health Organization (WHO), American Thoracic Society (ATS), United States Center for Diseases Control (U.S. CDC), Infectious Diseases Society of America (IDSA) and European Respiratory Society (ERS) include 2 months of isoniazid, rifampin, pyrazinamide and ethambutol (HREZ), followed by 4 months of isoniazid, rifampin, and ethambutol(HRE). The current treatment regimen requires 6 months of treatment, despite being highly efficacious, requires long duration of treatment. Adherence to treatment is the major barrier which poses a negative impact to TB control, and increased cost to both the patient and the public health system. Developing an efficacious, safe and short treatment regimen can significantly improve TB management and treatment success rates.
This description comes directly from the study's public registry record.
Susan Shin-Jung Lee, M.D., Ph.D. · +886-7342-2121 · ssjlee28@yahoo.com.tw
Mei-Ling Lin, University · +886-7342-2121 · ed101622@gmail.com
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| Far Eastern Memorial Hospital | New Taipei City, Bangiao, Taiwan | Recruiting |
| Taichung Hospital | Taichung, West, Taiwan | Recruiting |
| E-DA Healthcare Group | Kaoshiung, Yanchao, Taiwan | Recruiting |
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung City, Taiwan | Recruiting |
| Kaohsiung Veterans General Hospital | Kaohsiung City, Taiwan | Recruiting |
| Taipei Veterans General Hospital | Taipei, Taiwan | Recruiting |
| National Taiwan University Hospital | Taipei, Taiwan | Recruiting |
| Linkou Chang Gung Memorial Hospital | Taoyuan City, Taiwan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06727864