Condition: Breast Cancer · Locally Advanced Breast Cancer · Cognitive Impairment · Sponsor: UNC Lineberger Comprehensive Cancer Center
This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomarkers. Ninety stage I-III breast cancer patients during chemotherapy will be randomized into three groups: MEM+EX, memantine, or placebo. The study will evaluate recruitment, retention, adherence, acceptability, cognitive function, brain-derived neurotrophic factor (BDNF), inflammatory markers, and frailty at multiple time points.
This description comes directly from the study's public registry record.
Ashley M Hanson · +1 984-888-9244 · Ashley_Hanson@med.unc.edu
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| Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill | Chapel Hill, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06727773