Condition: Chronic Kidney Disease Associated Anemia · Sponsor: Shanghai Zhongshan Hospital
The CANNON trial is a prospective, open-label, randomized, multicenter study designed to investigate rational hemoglobin target value in patients with anemia of non-dialysis chronic kidney disease treated with enarodustat. Eligible patients are randomly assigned 1:1 to the high-hemoglobin target group （hemoglobin of 13 g/dl）and low-hemoglobin target group （hemoglobin of 11 g/dl）and administered with enarodustat to achieve and maintain target hemoglobin over 96 weeks. The first primary endpoint was the difference of mean change in 36-Item Short Form Health Survey at week 24. The second primary endpoint was safety endpoints included time to major adverse cardiovascular + event (MACE+; all-cause mortality, myocardial infarction, stroke, and congestive heart failure requiring hospitalization) during 96 weeks.
This description comes directly from the study's public registry record.
Xiaoqiang Ding · 008613816209067 · ding.xiaoqiang@zs-hospital.sh.cn
Xiaoyan Zhang · 008613918251317 · zhang.xiaoyan@zs-hospital.sh.cn
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| Zhongshan hospital, Fudan University | Shanghai, Shanghai Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06725810