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Study identifier: NCT06725277 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The OBSERVE Protocol

Condition: Major Depression Disorder  ·  Sponsor: Yale University

PhaseN/A
Planned participants450
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

This observational protocol is intended to provide long-term follow-up data on patients initiating or continuing treatment with either Spravato® or IV ketamine. This can provide us information on the patient acceptability and satisfaction, patterns of use, long-term effectiveness, and safety of the two approaches. This 5-year, 6-site study will enroll 450 total patients. The sites will comprise 3 academic medical centers and 3 community psychiatric practices.

This description comes directly from the study's public registry record.

Talk to the study team

Cindy Voghell  ·  203-737-4784  ·  cynthia.voghell@yale.edu

Always discuss trial participation with your own doctor first.

Locations (6)

Mood InstituteMilford, Connecticut, United StatesRecruiting
Yale School of MedicineNew Haven, Connecticut, United StatesRecruiting
Emory UniversityAtlanta, Georgia, United StatesRecruiting
University of MichiganAnn Arbor, Michigan, United StatesRecruiting
LifeStance HealthMoore, Oklahoma, United StatesRecruiting
Houston Center for Advanced Psychiatric TreatmentBellaire, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06725277