Condition: Fibrodysplasia Ossificans Progressiva (FOP) · Sponsor: University of California, San Francisco
This is an observational pre-post study to observe if the off label use of anti-IL1 therapies, such as anakinra or canakinumab, can block ACVR1-induced flare activity and heterotopic ossification in FOP. It will also generate key tools and preliminary data that are needed to design a future Phase II study. This study specifically focuses on patients with severe FOP who are being considered by their medical team for rescue therapy with anti-IL1 therapy. Preliminary data suggests patients experience significant decreases in flare frequency when taking anti-IL1 therapy, but other measures of efficacy remain unassessed, such as changes in heterotopic ossification formation, changes in pain medication use, and changes in functionality.
This description comes directly from the study's public registry record.
Samantha Klein · 415-254-5748 · Samantha.klein@ucsf.edu
Judy Gonzalez-Vargas · 415-254-5048 · Judy.Gonzalez-Vargas@ucsf.edu
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| UCSF | San Francisco, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06724562