Condition: Delirium, Postoperative · Delirium in Old Age · Sponsor: Beth Israel Deaconess Medical Center
Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) following heart surgery. Investigators aim to test a bundle of sleep optimization, cognitive exercise before surgery, and extended pain relief for 48 hours with intravenous acetaminophen combined with enhanced recovery after surgery protocols (SCOPE bundle). SCOPE will fill significant gaps in evidence by testing the value of a patient and care-provider-focused intervention that can potentially minimize POD and improve outcomes (cognitive \& physical function, sleep quality, pain, depression or anxiety, and survival) important to patients and families. The SCOPE trial will address many heart surgery outcome-related questions commonly asked by patients: What can I do to reduce my chances of developing confusion, hallucinations, or delirium after surgery? How can I best prepare before surgery to improve my long-term health and avoid disability? Are there exercises I can participate in that improve my sleep, pain, and mood after surgery? Intellectual pursuits, physical activity, and social interactions support cognitive reserve, while poor health, poor sleep hygiene, poor nutrition, and mental health disease can diminish reserve. Various interventions with different intensities and timing to augment cognitive reserve have been associated with positive outcomes on neuropsychological te…
This description comes directly from the study's public registry record.
Balachundhar Subramaniam, MD/MPH · 7814750572 · bsubrama@bidmc.harvard.edu
Priyam Mathur, MS · 3176035545 · pmathur@bidmc.harvard.edu
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| Massachusetts General Hospital | Boston, Massachusetts, United States | Recruiting |
| Columbia University Irving Medical Center | New York, New York, United States | Recruiting |
| The Ohio State University | Columbus, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06721819