Condition: KRAS G12C Mutation · KRAS G12S Mutation · Solid Tumor Malignancies · Sponsor: Kumquat Biosciences Inc.
The goal of this clinical trial is to learn if KQB365 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB365. The main questions it aims to answer are: * What is the safe dose of KQB365 by itself, in combination with cetuximab, or in combination with KQB198? * Does KQB365 alone, in combination with cetuximab, or in combination with KQB198 decrease the size of the tumor? * What happens to KQB365 in the body? Participants will: * Receive KQB365 infusion weekly alone, in combination with cetuximab, or in combination with oral KQB198. * Visit the clinic about 9 times in the first 6 weeks, and then once every week after that.
This description comes directly from the study's public registry record.
Kumquat Clinical Development · (858) 214-2700 · kumquatstudies@kumquatbio.com
Always discuss trial participation with your own doctor first.
| Mayo Clinic, Phoenix | Phoenix, Arizona, United States | Recruiting |
| Sarah Cannon Cancer Institute at HealthONE | Denver, Colorado, United States | Recruiting |
| Mayo Clinic, Jacksonville | Jacksonville, Florida, United States | Recruiting |
| Dana Farber Cancer Institute | Boston, Massachusetts, United States | Recruiting |
| START Midwest | Grand Rapids, Michigan, United States | Recruiting |
| Mayo Clinic, Rochester | Rochester, Minnesota, United States | Recruiting |
| Cleveland Clinic, Taussig Cancer Institute | Cleveland, Ohio, United States | Recruiting |
| OU Health Stephenson Cancer Center | Oklahoma City, Oklahoma, United States | Recruiting |
| Sydney Kimmel Cancer Center | Philadelphia, Pennsylvania, United States | Recruiting |
| NEXT Oncology | San Antonio, Texas, United States | Recruiting |
| NEXT Virginia, LLC | Fairfax, Virginia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06720987