Condition: Liver Transplantation · HCC · Oncological Outcomes · Sponsor: Philipp Dutkowski
Liver transplantation is often performed to treat liver cancer, or hepatocellular carcinoma (HCC), in patients with impaired liver function due to cirrhosis. A shortcoming, however, is tumor recurrence after transplantation. Approximately 15 % of patients receiving livers develop recurrence and this depends on the quality of the liver received. Machine liver perfusion, for example, hypothermic oxygenated liver perfusion (HOPE), which means that the organ is perfused with an oxygen-rich fluid in a cold environment before transplantation, is a novel method to improve the quality of livers before implantation. The standard of care is cold storage without perfusion. The objective of this study is to compare the survival after tumor recurrence of patients after liver transplantation for HCC between perfused and not perfused livers. This study's hypothesis is that survival without tumor recurrence is improved when the liver is perfused before implantation. The study involves transplant centers worldwide, and adults with HCC waiting for liver transplantation are included. 220 Patients will be recruited within 12 months and then observed for at least 2 years after transplantation. To provide the most valid results, the patients will be randomly allocated to either the organ perfusion group or a control group with standard-of-care cold storage of the organ.
This description comes directly from the study's public registry record.
Philipp Dutkowski, Professor · 0041 61 777 73 06 · philipp.dutkowski@clarunis.ch
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| Rutgers New Jersey Medical School (New York) | New York, New York, United States | Not Yet Recruiting |
| Cleveland Clinic | Cleveland, Ohio, United States | Not Yet Recruiting |
| Medical University of Innsbruck | Innsbruck, Austria | Recruiting |
| Medical University of Vienna | Vienna, Austria | Recruiting |
| University Hospitals Leuven | Leuven, Belgium | Recruiting |
| Institut de Recherche Expérimentale et Clinique (IREC) UCLouvain (Brussels) | Woluwe-Saint-Lambert, Belgium | Recruiting |
| Institute for Clinical and Experimental Medicine (IKEM) (Prague) | Prague, Czechia | Recruiting |
| Copenhagen University Hospital | Copenhagen, Denmark | Recruiting |
| Hôpital de la Croix-Rousse (Lyon) | Lyon, France | Not Yet Recruiting |
| Universitätsklinikum Essen | Essen, Germany | Not Yet Recruiting |
| University Medical Centre Hamburg-Eppendorf | Hamburg-Eppendorf, Germany | Not Yet Recruiting |
| Hannover Medical School | Hanover, Germany | Not Yet Recruiting |
+ 25 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06717919