Condition: Preeclampsia (PE) · Sponsor: iPremom
Preeclampsia (PE) is a major obstetric complication with severe short- and long-term consequences for both mother and fetus. Early detection is critical to mitigate PE-related morbidity and mortality. Effective screening tools are needed to identify women at risk, enabling timely preventive and therapeutic interventions. Current screening methods primarily target placental biomarkers like sFLT1 and PlGF, which are limited to short-term predictions near symptom onset. Existing first-trimester assessments that incorporate maternal factors and Doppler metrics remain constrained by low sensitivity (\<41%) in compliance with NICE and ACOG guidelines. Recent advancements in cell free RNA (cf-RNA) analysis have revealed potential in first-trimester PE prediction. Findings from the PREMOM study (NCT04990141) established a molecular profile for early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) through cfRNA analysis, culminating in the development of the MaiRa Preeclampsia Test (Maternal Advanced and Innovative Preeclampsia Risk Assessment), which demonstrated high predictive performance for first- and second-trimester screening. The current study hypothesizes that the MaiRa Preeclampsia Test is generalizable, maintaining its predictive accuracy in an independent cohort.
This description comes directly from the study's public registry record.
Clinical Studies Department · +34 636 260 481 · clinicalstudies@ipremom.com
Érika Ortiz Domingo · +34 636 260 481 · erika.ortiz@mshareservices.es
Always discuss trial participation with your own doctor first.
| Hospital General Universitario Dr. Balmis | Alicante, Alicante, Spain | Recruiting |
| Hospital de la Santa Creu i Sant Pau | Barcelona, Barcelona, Spain | Recruiting |
| Hospital Comarcal de Vinaròs | Vinaròs, Castellón, Spain | Recruiting |
| Hospital Universitario Puerta del Mar | Cadiz, Cádiz, Spain | Recruiting |
| Hospital Universitario A Coruña | A Coruña, La Coruña, Spain | Recruiting |
| Hospital Universitario de Torrejón | Torrejón de Ardoz, Madrid, Spain | Recruiting |
| Hospital Clínico Universitario Virgen de la Arrixaca | El Palmar, Murcia, Spain | Recruiting |
| Hospital Universitario de Canarias | San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain | Recruiting |
| Hospital de Manises | Manises, Valencia, Spain | Recruiting |
| Hospital Universitario Doctor Peset | Valencia, Valencia, Spain | Recruiting |
| Hospital Universitario y Politécnico La Fe | Valencia, Valencia, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06716242