Condition: Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery · Sponsor: B.P. Koirala Institute of Health Sciences
Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response. Use of corticosteroids decrease tissue mediators of inflammation and reduce edema. Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.
This description comes directly from the study's public registry record.
sabin baniya, mds · +977-9841134900 · sabinmds785@gmail.com
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| Bp Koirala Institute of Health Sciences | Dharān, Koshi, Nepal | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06713733