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Study identifier: NCT06712355 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

Condition: Extensive-stage Small-cell Lung Cancer  ·  Sponsor: BioNTech SE

PhasePhase 3
Planned participants621
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).

This description comes directly from the study's public registry record.

Talk to the study team

BioNTech clinical trials patient information  ·  +49 6131 9084  ·  patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (221)

ACRC Arizona Clinical Research CenterTucson, Arizona, United StatesRecruiting
Clermont Oncology CenterClermont, Florida, United StatesTerminated
Cancer Care Centers of Brevard, IncPalm Bay, Florida, United StatesRecruiting
Northside Hospital AtlantaAtlanta, Georgia, United StatesRecruiting
Illinois Cancer SpecialistsNiles, Illinois, United StatesRecruiting
Fort Wayne Medical Oncology and Hematology, IncFort Wayne, Indiana, United StatesRecruiting
McFarland ClinicAmes, Iowa, United StatesRecruiting
Helen G. Nassif Community Cancer CenterCedar Rapids, Iowa, United StatesRecruiting
Baptist Health Hardin Cancer CenterElizabethtown, Kentucky, United StatesRecruiting
LSU Health Baton Rouge - North ClinicBaton Rouge, Louisiana, United StatesRecruiting
Our Lady of the Lake Hospital, Inc.Baton Rouge, Louisiana, United StatesRecruiting
Frederick Health Hospital- James M Stockman Cancer InstituteFrederick, Maryland, United StatesRecruiting

+ 209 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06712355