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Study identifier: NCT06711887 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study Treatment Withdrawal in Participants With Lupus Nephritis (SIRIUS-LN Extension)

Condition: Lupus Nephritis  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants348
Who can joinAll sexes, 18 Years to 100 Years
Healthy volunteersNo

About this study

The purpose of this up to 6-year extension study is the evaluation of the efficacy and safety 1. after study treatment withdrawal in patients with lupus nephritis (LN) who achieved response (complete renal response \[CRR\] or partial renal response \[PRR\]) on double-blind treatment at the end of the SIRIUS-LN core study, and 2. of open-label ianalumab 300 mg treatment in patients who, at the end of the SIRIUS-LN core study, were either already receiving ianalumab open-label treatment or did not meet CRR/PRR criteria on double-blind treatment at the end of the SIRIUS-LN core study.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Always discuss trial participation with your own doctor first.

Locations (41)

Circuit ClinicalOrchard Park, New York, United StatesRecruiting
Novartis Investigative SiteVitória, Espírito Santo, BrazilRecruiting
Novartis Investigative SiteSalvador, Estado de Bahia, BrazilRecruiting
Novartis Investigative SiteBelo Horizonte, Minas Gerais, BrazilRecruiting
Novartis Investigative SiteSanto André, São Paulo, BrazilRecruiting
Novartis Investigative SiteGuangzhou, Guangdong, ChinaRecruiting
Novartis Investigative SiteShantou, Guangdong, ChinaActive Not Recruiting
Novartis Investigative SiteShenzhen, Guangdong, ChinaRecruiting
Novartis Investigative SiteLiuzhou, Guangxi, ChinaRecruiting
Novartis Investigative SiteWuhan, Hubei, ChinaRecruiting
Novartis Investigative SiteChangchun, Jilin, ChinaRecruiting
Novartis Investigative SiteBinzhou, Shandong, ChinaRecruiting

+ 29 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06711887