Condition: Cardiac Arrest · Sponsor: Qilu Hospital of Shandong University
Neurological injury remains an important cause of morbidity and mortality in patients with ECPR. At present, the results of three prospective randomized controlled studies on ECPR are inconsistent, and it is inconclusive whether ECPR can improve the neurological outcomes of patients with refractory cardiac arrest. Several study found that extracorporeal membrane oxygenation nonsurvivors can lead toacute brain injury.Further research with a systematic neurologic monitoring is necessary to define the timing of acute brain injury in patients with extracorporeal membrane oxygenation.Moreover, brain injury that occurs during extracorporeal membrane oxygenation therapy is not easy to detect in time because of the use of analgesics, sedatives, and muscle relaxants. Surprisingly, little attention has been paid to the role of cerebral perfusion and oxygenation. Moreover,the features of cerebrovascular pathophysiology and optimal management strategies are still vague. Therefore multimodal neuromonitoring may be a valuable tool for detecting brain injury in patients with extracorporeal membrane oxygenation and providing early intervention guidance. Multimodal neuromonitoring, integrating tools such as near-infrared spectroscopy (NIRS), transcranial Doppler, and continuous electroencephalography, may enable early detection of brain injury and guide targeted interventions. Hypothesis: Multimodal neuromonitoring combined with a standard care management will increase the proportion of pa…
This description comes directly from the study's public registry record.
Xianfei Ji, MD. PhD · 0086-531-82165072 · qlyyjxf@163.com
Feng Xu, MD. PhD · 86-0531-82165675 · xufengsdu@126.com
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| Qilu Hospital | Jinan, Shandong, China | Not Yet Recruiting |
| Qilu hospital | Jinan, Shandong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06711016