Condition: Systemic Lupus Erythematous (SLE) · Sponsor: National University of Malaysia
This pilot clinical study aims to evaluate the effectiveness of Chimeric Antigen Receptor (CAR) T-cell therapy in treating severe, refractory systemic lupus erythematosus (SLE), an autoimmune disease driven by autoreactive B-cells. Current treatments for severe SLE, including glucocorticoids, cytotoxic, and immunosuppressive drugs, have significant limitations. These treatments do not adequately control the underlying autoimmune process and require long-term use, leading to chronic side effects and often failing to prevent permanent organ damage. Given the high prevalence and mortality rates associated with SLE in regions like Asia and Malaysia, there is a pressing need for more effective therapies.
This description comes directly from the study's public registry record.
S Fadilah Abdul Wahid, PhD · +60391456450 · sfadilah@hctm.ukm.edu.my
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| University Kebangsaan Malaysia Medical Center | Bandar Tun Razak, Kuala Lumpur, Malaysia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06710717