Condition: NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI) · Acute Myocardial Infarction (AMI) · Sponsor: University of Aarhus
The main goal of this study is to compare two treatments in patients with a specific type of heart attack called Non-ST-elevation Myocardial Infarction (NSTEMI). The investigators want to find out whether using aspirin alone is as effective and safer than using aspirin together with a second blood thinner called fondaparinux. Both treatments will be given before a scheduled heart procedure called coronary angiography (CAG), which may include balloon dilation and stent placement (PCI) if needed. The current guidelines recommend using aspirin in combination with a second blood thinner like fondaparinux before CAG and possible PCI. However, these recommendations are based on studies from the 1990s, a time when invasive procedures were not standard practice for these patients. In contrast, nearly all patients with NSTEMI in Denmark (96%) now undergo CAG within 72 hours. This change in practice raises questions about whether the older studies still provide a valid foundation for today's guidelines. The study aims to answer two questions: 1. Is aspirin alone as effective as aspirin combined with fondaparinux before early CAG and possible PCI? 2. Is aspirin alone safer, with a lower risk of severe bleeding, compared to the combination treatment? To answer these questions, the investigators will enroll about 5,000 patients with NSTEMI. Participants will be randomly assigned to receive either aspirin alone or aspirin with fondaparinux. The investigators will monitor them for 30 d…
This description comes directly from the study's public registry record.
Christian B Fur, MD · +4524918071 · chbyni@rm.dk
Christian J Terkelsen, MD, PhD, DmSC · christian.terkelsen@skejby.rm.dk
Always discuss trial participation with your own doctor first.
| Regionshospitalet Gødstrup | Herning, Region Midt, Denmark | Recruiting |
| Regionshospitalet Horsens | Horsens, Region Midt, Denmark | Not Yet Recruiting |
| Regionshospitalet Viborg | Viborg, Region Midt, Denmark | Recruiting |
| Aalborg Universitetshospital | Aalborg, Region Nord, Denmark | Not Yet Recruiting |
| Sygehus Søndejylland, Aabenraa | Aabenraa, Region Syd, Denmark | Recruiting |
| Esbjerg Sygehus | Esbjerg, Region Syd, Denmark | Not Yet Recruiting |
| Sygehus Lillebælt, Kolding | Kolding, Region Syd, Denmark | Recruiting |
| Odense Universitetshospital | Odense, Region Syd, Denmark | Recruiting |
| Sygehus Lillebælt, Vejle | Vejle, Region Syd, Denmark | Recruiting |
| Aarhus University Hospital, Department of Cardiology | Aarhus N, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06710184