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Study identifier: NCT06709885 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

HDAC Inhibitor Combination With Chemoimmunotherapy in the Neoadjuvant Treatment of pMMR Locally Advanced Colon Cancer

Condition: Colon Adenocarcinoma  ·  Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

PhasePhase 2
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this clinical trial is to learn the safety and efficacy of HDAC inhibitors in combination with neoadjuvant immunochemotherapy compared to neoadjuvant therapy in the treatment of locally advanced colon cancer. The main questions it aims to answer are: Can HDAC inhibitors combined with neoadjuvant immunochemotherapy improve the rate of pCR and complete resection in patients? Are HDAC inhibitors combined with neoadjuvant immunochemotherapy safe and reliable? Does the combination of HDAC inhibitors and neoadjuvant immunochemotherapy achieve a better long-term prognosis than neoadjuvant therapy?

This description comes directly from the study's public registry record.

Talk to the study team

fan li, PhD  ·  18696539200  ·  levinecq@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Daping Hospital, Third Military Medical UniversityChongqing, Chongqing Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06709885