Condition: Stage I Ovarian Cancer · Borderline Ovarian Tumors · Sponsor: KU Leuven
The study aims to improve the diagnosis of ovarian cancer by distinguishing between borderline ovarian tumors (BOT) and stage I invasive ovarian cancer. Other than the traditional diagnostic biomarker CA125, the previous study TRANS-IOTA (translational-international ovarian tumor analysis; S51375/S59207), conducted by similar investigators, pointed at biomarkers like HE4, CA72.4, CA15.3, and CCL11, as potential markers to discriminate BOT from stage I cancer. BIOC is the follow-up study, which will include four additional promising biomarkers to expand the panel to nine. The investigators aim to confirm whether a subpanel of these nine biomarkers has diagnostic value. Such a biomarker signature would enhance the accuracy of distinguishing between BOT and stage I invasive ovarian cancer before surgery, leading to more precise treatment and improved patient outcomes.
This description comes directly from the study's public registry record.
An Coosemans · +32 16 37 77 88 · an.coosemans@kuleuven.be
Kainat Jamil · +32 16 37 39 88 · kainat.jamil@kuleuven.be
Always discuss trial participation with your own doctor first.
| UZ Leuven | Leuven, Flemish Brabant, Belgium | Recruiting |
| General Faculty Hospital of the Charles University | Prague, Czechia | Recruiting |
| Istituto Nazionale dei Tumore | Milan, Italy | Not Yet Recruiting |
| Università Cattolica del Sacro Cuore | Rome, Italy | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06709872