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Study identifier: NCT06708949 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Randomized Phase 2 Trial of Nivolumab, Relatlimab Plus Ipilimumab vs. Nivolumab Plus Ipilimumab in First-line Advanced Renal Cell Carcinoma (RCC)

Condition: Renal Cell Carcinoma, Clear Cell  ·  Sponsor: M.D. Anderson Cancer Center

PhasePhase 2
Planned participants15
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase 2 stratified, randomized, multicenter, study investigating the efficacy of a triplet arm treating with nivolumab 480 mg every 4 weeks (Q4W), relatlimab 160 mg Q4W and ipilimumab 1 mg/kg every 8 weeks (Q8W) intravenous (IV) versus a doublet arm treating with nivolumab 480 mg Q3W and ipilimumab 1mg/kg Q3W IV in first-line advanced RCC.

This description comes directly from the study's public registry record.

Talk to the study team

Eric Jonasch, MD  ·  (713) 563-7232  ·  ejonasch@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (6)

Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Duke University Medical CenterDurham, North Carolina, United StatesRecruiting
Penn Medicine Abramson Cancer CenterPhiladelphia, Pennsylvania, United StatesRecruiting
Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting
University of Texas Southwestern Medical CenterDallas, Texas, United StatesRecruiting
The University of Texas M. D. Anderson Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06708949