Condition: Severe Hemophilia A · Sponsor: Pfizer
The purpose of the study is to learn about safety, how the body processes marstacimab and how it works in patients with severe hemophilia A without inhibitors. Hemophilia A is rare bleeding disorder where the blood doesn't clot normally. This causes a person to bleed a lot, even from a small cut. These patients who are on emicizumab medicine for routine prophylaxis for at least 6 months, and desire to switch to marstacimab medicine. Inhibitors are antibodies that the immune system develops because it sees the infused clotting factor as a foreign substance that needs to be destroyed. Antibodies are proteins that eat up the activated factor before it has time to stop the bleeding. Prophylaxis are preventive medicines. This study is seeking for participants: * with severe Hemophilia A withouth inhibitors who are on emicizumab treatment for at least 6 months. * must be 12 to less than 75 years old * must have a body weight of at least 35 kilograms. The results from this study will serve as a guide to doctors and their hemophilia A patients who will change their medicines in the real-world clinical setting. Patients who can take part in the study will receive marstacimab medicine as weekly injections under the skin of 150 milligrams for 4 months. Study treatment with marstacimab will be initiated no earlier than 14 days after last dose of emicizumab. The study can last up to 6 months. The sponsor will provide marstacimab. Patients will continue their usual treatment with the in…
This description comes directly from the study's public registry record.
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| Orthopaedic Institute for Children/Orthopaedic Hemophilia Treatment Center | Los Angeles, California, United States | Recruiting |
| Brody School of Medicine at East Carolina University | Greenville, North Carolina, United States | Recruiting |
| ECU Health Medical Center | Greenville, North Carolina, United States | Recruiting |
| Nirmal Hospital Pvt Ltd. | Surat, Gujarat, India | Recruiting |
| K J Somaiya Hospital & Research Centre | Mumbai, Maharashtra, India | Recruiting |
| Ege University Faculty of Medicine Dean's Office | Bornova, İzmir, Turkey (Türkiye) | Recruiting |
| Istanbul Universitesi Tıp Fakultesi Onkoloji Enstitusu | Fatih, İ̇stanbul, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06703606