Condition: Nitric Oxide · Cardiac Surgery · Cardiopulmonary Bypass · Sponsor: Xijing Hospital
Cardiac surgery is a procedure that is commonly performed worldwide. Despite these technological advances, cardiac surgery remains a high-risk surgery. Among post-operative complications, acute kidney injury, respiratory failure, myocardial infarction, and stroke as well as cognitive dysfunction are significant causes of mortality in patients undergoing and following cardiac surgery. Inhaled nitric oxide (NO) therapy as a selective pulmonary vasodilator in cardiac surgery has been one of the most significant pharmacological advances in managing pulmonary hemodynamics and life threatening right ventricular dysfunction and failure. In addition, newer applications show greater promise of inhaled NO as a therapy in the area of cardiac surgery associated acute kidney injury and ischemia reperfusion. However, this remarkable expectation to inhaled NO has experienced a roller-coaster ride with high hopes and nearly universal demonstration of physiological benefits but disappointing translation of these benefits to harder clinical outcomes, like mortality. Most of our understanding on the iNO field in cardiac surgery stems from small observational or single center randomized trials, which failed to ascertain strong evidence base. As a consequence, there are only week clinical practice guidelines on the field and only European expert opinion for the use of iNO in routine and more specialized cardiac surgery. There is need for a large multicenter randomized controlled study to confirm …
This description comes directly from the study's public registry record.
Chong Lei, M.D., & phd · 18629011362 · crystalleichong@126.com
ziyu Zheng, ph.D. · 13228082320 · zhengziyu@126.com
Always discuss trial participation with your own doctor first.
| Massachusetts General Hospital, Department of Anesthesia, Critical Care and Pain Medicine | Boston, Massachusetts, United States | Not Yet Recruiting |
| Xijing Hospital | Xi'an, Shaanxi, China | Recruiting |
| Cardiology Research Institute, Tomsk National Research Medical Center | Tomsk, Russia | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06702553