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Study identifier: NCT06700538 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A First-In-Human Study of ARO-INHBE in Adults With Obesity With and Without Type 2 Diabetes Mellitus

Condition: Obesity  ·  Sponsor: Arrowhead Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants180
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This is a Phase 1/2a double-blind dose-escalating study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of ARO-INHBE in adult participants with obesity (in Part 1), the safety, tolerability, PK, and PD of multiple doses of ARO-INHBE either as monotherapy, or in combination with tirzepatide, in adult participants with obesity with and without type 2 diabetes mellitus (in Part 2 and Part 3).

This description comes directly from the study's public registry record.

Talk to the study team

Medical Monitor  ·  626-304-3400  ·  AROINHBE@arrowheadpharma.com

Always discuss trial participation with your own doctor first.

Locations (5)

Research Site 1Grafton, Auckland, New ZealandRecruiting
Research Site 5Auckland, New ZealandRecruiting
Research Site 3Auckland, New ZealandRecruiting
Research Site 2Christchurch, New ZealandRecruiting
Research Site 4Hamilton, New ZealandRecruiting

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Source record: clinicaltrials.gov/study/NCT06700538