Condition: Acute Respiratory Distress Syndrome (ARDS) · Acute Respiratory Failure with Hypoxia · Sponsor: Ricard Mellado Artigas
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease. Some people with this condition may need to be intubated and connected to invasive mechanical ventilation, but less severe cases may need supplementary oxygen that can be delivered with non-invasive devices, such as CPAP (continuous positive airway pressure) or HFNO (high flow nasal oxygenation). CPAP consists on a facemask that provides oxygen-enriched air at a high pressure, whereas HFNO consists on nasal cannula that provides oxygen-enriched air at a high flow. Patients with ARDS may present with high respiratory efforts that can eventually damage their own lungs and contribute to the development of a phenomenon known as patient self-inflicted lung injury (P-SILI). Previous research has identified that CPAP may be successful in attuenuating P-SILI compared to HFNO, but it is not known whether this attenuation actually results into a reduction in lung injury in real patients. In this multicentre trial, 120 non-intubated patients with stablished ARDS will be randomly assigned to receive oxygen-enriched air through either CPAP or HFNO for 48 hours plus standard intensive care. The primary goal of this study is to determine the pulmonary effect of CPAP and HFNO through lung injury biomarkers that can be detected in blood, such as sRAGE (soluble Receptor of Advanced Glycation End-products), angiotensin-II, interleukin-6 and in…
This description comes directly from the study's public registry record.
Ricard Mellado Artigas, PhD · +34 646217716 · rmellado@clinic.cat
Jordi Vallverdú Martínez, MD · +34 622929752 · vallverdu@clinic.cat
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| Hospital Clínic de Barcelona | Barcelona, Barcelona, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06694311