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Study identifier: NCT06691217 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis

Condition: Vascular Inflammation · ASCVD · ASCVD Management  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants120
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary goal of this clinical trial is to test the hypothesis that the drug canakinumab (anti-IL-1B monoclonal antibody) decreases vascular inflammation when used by people with a history of coronary artery disease, including those with and without clonal hematopoiesis driven by mutations in TET2.

This description comes directly from the study's public registry record.

Talk to the study team

Michael C Honigberg, MD MPP  ·  617-726-1843  ·  mhonigberg@mgh.harvard.edu

Mabel Toribio, MD  ·  (617)-724-2826  ·  mptoribio@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06691217