Condition: Puberty · Healthy · Stress · Sponsor: International Research Training Group 2804
Pubertal transition leads to enduring neuroendocrine changes along with changes in the epigenome. The prevalence of psychiatric disorders significantly increases in females compared to males after puberty. There is likely to be an interaction between epigenetics, hormones and neurophysiological processes during puberty, leading to the increased prevalence of mental disorders in females. This study aims to shed light on these interactions underlying the emerging sex differences after puberty. Specifically, it seeks to investigate the epigenetic modifications and subsequent changes in gene expression during the pubertal transition and their association with negative emotionality (e.g., acute stress response and depressive symptoms) at molecular, neuronal, subjective and physiological levels.
This description comes directly from the study's public registry record.
Vanessa Nieratschker, Prof. Dr. · +497071-2985523 · vanessa.nieratschker@med.uni-tuebingen.de
Birgit Derntl, Prof. Dr. · +497071 29-85437 · birgit.derntl@med.uni-tuebingen.de
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| University of Tuebingen; Department of Psychiatry & Psychotherapy; Tuebingen | Tübingen, Baden-Wurttemberg, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06690866