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Study identifier: NCT06686394 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

Condition: Breast Neoplasms · Breast Cancer  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 1/Phase 2
Planned participants81
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers want to learn if patritumab deruxtecan (MK-1022) can treat certain breast cancers. The breast cancers being studied are HER2 positive unresectable locally advanced or metastatic (the cancer has spread to other parts of the body). The goals of this study are to learn: * About the safety and how well people tolerate of patritumab deruxtecan * How many people have the cancer respond (get smaller or go away) to treatment

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (18)

University of Colorado Anschutz Medical Campus ( Site 0057)Aurora, Colorado, United StatesRecruiting
Dana-Farber Cancer Institute ( Site 0050)Boston, Massachusetts, United StatesRecruiting
Rutgers Cancer Institute of New Jersey ( Site 0052)New Brunswick, New Jersey, United StatesRecruiting
Prisma Health - Upstate (ITOR)_Edenfield ( Site 0053)Greenville, South Carolina, United StatesRecruiting
Inova Schar Cancer Institute ( Site 0051)Fairfax, Virginia, United StatesRecruiting
Kingston General Hospital ( Site 0061)Kingston, Ontario, CanadaRecruiting
Princess Margaret Cancer Centre ( Site 0001)Toronto, Ontario, CanadaRecruiting
Centre Hospitalier de l'Université de Montréal ( Site 0004)Montreal, Quebec, CanadaRecruiting
Jewish General Hospital ( Site 0003)Montreal, Quebec, CanadaRecruiting
Rambam Health Care Campus ( Site 0011)Haifa, IsraelRecruiting
Rabin Medical Center ( Site 0012)Petah Tikva, IsraelRecruiting
Sheba Medical Center ( Site 0010)Ramat Gan, IsraelRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06686394