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Study identifier: NCT06684470 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

Condition: IBS - Irritable Bowel Syndrome · Diarrhea  ·  Sponsor: Mayo Clinic

PhaseEARLY_Phase 1
Planned participants20
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

The purpose of this research is to study the added benefit of treating IBS symptoms with a medication called mirtazapine in treating IBS symptoms when paired with a low-FODMAP diet compared to a low-FODMAP diet alone. FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. These are short-chain carbohydrates that can cause digestive distress in some people. You have been asked to take part in this research because you have symptoms of diarrhea-predominant irritable bowel syndrome that may respond to treatment with a combination of a medication called mirtazapine and a low-FODMAP diet.

This description comes directly from the study's public registry record.

Talk to the study team

Jessica C Petrov, MD  ·  904-953-2000  ·  Petrov.Jessica@mayo.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Mayo ClinicJacksonville, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06684470