Condition: Irritable Bowel Syndrome (IBS) · Irritable Bowel Syndrome of Diarrhea Type (IBS-D) · Sponsor: Devintec Sagl
Irritable Bowel Syndrome (IBS) is one of the major Disorders of Gut-Brain Interaction (DGBI) and the most frequent reasons for referral to both primary care providers and gastroenterologists.IBS is not a life-threatening disease, but imposes a significant burden on society, entailing a decrease in patients' Quality of Life (QoL), elevated rates of psychological comorbidities and loss of work productivity, which might be the greatest in subjects with IBS-D, for whom the fear of incontinence in a social situation can be especially debilitating. Moreover, IBS is associated with significant direct and indirect healthcare costs and has a considerable socioeconomic impact on society. Treatment strategy for IBS is usually based on predominant symptoms and their severity, and requires a strong patient-physician relationship, as well as both non-pharmacological and pharmacological approaches. Lifestyle interventions, such as dietary modifications, physical activity and lifestyle adjustments, and stress reduction/psychological therapy represent the most important initial non-pharmacological clinical approach for IBS patients, especially for those with mild disease. First-line pharmacological options for IBS-D include antidiarrheals, mainly loperamide, to control diarrhoea, as well as antispasmodic drugs to relieve IBS symptoms, in particular abdominal pain. Second-line therapies indicated for the treatment of global IBS-D symptoms include rifaximin, 5-Hydroxytryptamine (5-HT)3 recepto…
This description comes directly from the study's public registry record.
Maria Dini · +39 3383236335 · maria.dini@prineos.com
Daniela Salvati · +39 3334828012 · daniela.salvati@prineos.com
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| University Hospitals Leuven (UZ Leuven) | Leuven, Belgium | Recruiting |
| Hôpital Avicenne | Bobigny, France | Recruiting |
| CHU de Rouen | Rouen, France | Recruiting |
| IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola | Bologna, BO, Italy | Recruiting |
| IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation | Milan, Italy | Recruiting |
| AOU Federico II di Napoli | Naples, Italy | Recruiting |
| Azienda Ospedale Università Padova | Padova, Italy | Recruiting |
| Fondazione IRCCS Policlinico San Matteo | Pavia, Italy | Recruiting |
| Azienda Ospedaliero Universitaria Pisana (AOUP) | Pisa, Italy | Recruiting |
| S. Andrea University Hospital | Roma, Italy | Recruiting |
| Hospital Universitario Vall d´Hebron | Barcelona, Spain | Recruiting |
| Hospital Universitario Ramón y Cajal | Madrid, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06681012