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Study identifier: NCT06680921 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of SIM0270 Combined With Everolimus vs. Treatment of Physician's Choice in Patients With ER+/HER2- Advanced Breast Cancer (SIMRISE)

Condition: Locally Advanced or Metastatic Breast Cancer  ·  Sponsor: Jiangsu Simcere Pharmaceutical Co., Ltd.

PhasePhase 3
Planned participants460
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This Phase III, randomized, open label, multicenter study will evaluate the efficacy and safety of SIM0270 combined with everolimus compared to physician's choice of treatment in subjects with ER+/HER2- locally advanced or metastatic breast cancer who have had previous treatment with CDK4/6 inhibitor.

This description comes directly from the study's public registry record.

Talk to the study team

JING WANG  ·  18624010252  ·  wangjing16f919@zaiming.com

Always discuss trial participation with your own doctor first.

Locations (60)

The First Affiliated Hispital of Bengbu Medical UniversityBengbu, Anhui, ChinaRecruiting
Anhui Provincial Cancer HospitalHefei, Anhui, ChinaRecruiting
The First Affiliated Hispital of Anhui Medical UniversityHefei, Anhui, ChinaRecruiting
Maanshan People's HospitalMaanshan, Anhui, ChinaRecruiting
Beijing Cancer HospitalBeijing, Beijing Municipality, ChinaRecruiting
The First Medical Center of PLA Ggeneral HospitalBeijing, Beijing Municipality, ChinaRecruiting
The First Affiliated Hospital of Chongqing Medical UniversityChongqing, Chongqing Municipality, ChinaRecruiting
The Second Affiliated Hospital of Chongqing Medical UniversityChongqing, Chongqing Municipality, ChinaRecruiting
Fujian Cancer HospitalFuzhou, Fujian, ChinaRecruiting
Fujian Provincial HospitalFuzhou, Fujian, ChinaRecruiting
The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou, Fujian, ChinaNot Yet Recruiting
Gansu Provincial Cancer HospitalLanzhou, Gansu, ChinaRecruiting

+ 48 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06680921