Condition: Endometrial Cancer · Genetic Predisposition · Risk Behavior · Sponsor: Lukas Vanek
Endometrial cancer (EC) is one of the most prevalent cancers in women worldwide with a significantly increasing incidence, especially in developed countries. One of the reasons for the increase in the incidence of this disease is the rising incidence of obesity as the biggest risk factor for the development of this disease. Other important risk factors are hypertension, diabetes mellitus and the general ageing of the population. These risk factors are not only associated with a higher risk of developing the disease, but also, for example, with post-operative complications affecting the quality of life of patients after surgery. The molecular classification of endometrial cancer, which has been introduced into clinical practice in recent years, is currently helping physicians to make treatment decisions for individual patients and predict prognosis. In this project, we would like to focus on the relationship of this molecular classification with genomic mutational signatures detected by whole-exome sequencing and their association with lifestyle risk factors for endometrial cancer (obesity - BMI, hypertension, diabetes mellitus), including the extent of staging lymphadenectomy. Identification and detailed analysis of dominant mutational profiles associated with a specific molecular subtype of EC and their influence on the presence of lifestyle risk factors may have a major impact on both disease development and prevention of disease recurrence. The possible relationship of the…
This description comes directly from the study's public registry record.
Michael Halaška, prof. MUDr. · +420 296472368 · michael.halaska@fnkv.cz
Věra Štěpánková · +42026716 2739 · vera.stepankova@fnkv.cz
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| Faculty Hospital Královské Vinohrady | Prague, Czechia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06680791