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Study identifier: NCT06680050 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase II Study of Radiotherapy Followed by Durvalumab and Ceralasertib in Stage III NSCLC Patients With Thoracic Relapses +/- Oligometastases After PACIFIC Regimen

Condition: Non Small Cell Lung Cancer NSCLC  ·  Sponsor: Mario Negri Institute for Pharmacological Research

PhasePhase 2
Planned participants21
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Aim of this phase 2 study is to explore the safety and efficacy of thoracic re-irradiation +/- SBRT to oligometastases (\<3) followed after an interval of 2 weeks by durvalumab and ceralasertib for patients with thoracic relapses +/- oligometastases after PACIFIC or PACIFIC-like (concurrent or sequential chemo-radiotherapy followed by maintenance durvalumab) regimens.

This description comes directly from the study's public registry record.

Talk to the study team

Irene De Simone, Project manager  ·  +39 02 39014661  ·  irene.desimone@marionegri.it

Always discuss trial participation with your own doctor first.

Locations (9)

ASST degli Spedali Civili di BresciaBrescia, ItalyNot Yet Recruiting
Azienda Ospedaliero Universitaria CareggiFlorence, ItalyRecruiting
IRCCS Ospedale Policlinico San Martino, GenovaGenova, ItalyRecruiting
ASST Grande Ospedale Metropolitano NiguardaMilan, ItalyRecruiting
Fondazione IRCCS Istituto Nazionale dei TumoriMilan, ItalyRecruiting
Azienda ospedaliera di PadovaPadova, ItalyNot Yet Recruiting
Azienda Ospedaliero - Universitaria di ParmaParma, ItalyNot Yet Recruiting
University Hospital of GenevaGeneva, SwitzerlandNot Yet Recruiting
University Hospital ZurichZurich, SwitzerlandNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06680050