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Study identifier: NCT06676696 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study to Compare the Outcome of Receiving Continued Immunosuppression Versus Stopping Immunosuppression at 6 Months to Safely Prevent Human Leukocyte Antigen (HLA) Sensitization in Patients With Late Renal Graft Failure

Condition: Renal Failure , Chronic · Graft Failure · Graft Rejection  ·  Sponsor: Hospital Universitari Vall d'Hebron Research Institute

PhasePhase 4
Planned participants202
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to compare the degree of HLA sensitization at 2 years in patients with late renal graft failure (\> 3 months) when receiving reduced immunosuppressant treatment versus stopping immunosuppression at 6 months. The main question this study aims to answer is: Does maintaining long-term immunosuppression in patients with a late renal graft failure (\> 3 months) safely reduce the risk of HLA sensitization? To answer this question, patients will be assigned to a control arm or investigational arm: * Patients assigned to the control arm will receive standard treatment, in which immunosuppressant treatment is withdrawn after 6 months. * Patients assigned to the investigatonal arm will continue immunosuppressant treatment at low doses for 2 years. Patients recruited in this clinical trial will be followed for up to 2 years. During this time, patients will visit the clinic every 3 months for checkups and tests.

This description comes directly from the study's public registry record.

Talk to the study team

Francesc Moreso, MD, PhD  ·  93 489 30 00  ·  francescjosep.moreso@vallhebron.cat

Always discuss trial participation with your own doctor first.

Locations (1)

Hospital Universitario Vall D'HebronBarcelona, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT06676696