Condition: Hypertension, Uncontrolled · Hypertension, Resistant · Hypertension · Sponsor: National Taiwan University Hospital
Our previous study (Huang HC, Pan HY, Wang TD, Circ Cardiovasc Interv 2023;16:e012779) demonstrated that when renal artery stimulation continues to trigger systolic blood pressure increases (\>=20 mmHg increase compared to baseline) after the initial procedure, patients show poor blood pressure reduction 6 months following renal denervation. Based on this finding, we designed a proof-of-concept trial comparing two approaches: a guided strategy versus conventional renal denervation. In the guided strategy, we perform additional ablations of main and/or branch renal arteries if immediate post-procedure stimulation still elevates systolic blood pressure (\>=20 mmHg increase compared to baseline). The conventional approach involves no repeat procedures. This trial aims to determine whether the guided strategy leads to better clinical outcomes, measured by 6-month ambulatory blood pressure changes, and to establish the value of using intraprocedural feedback to assess and guide renal denervation treatment.
This description comes directly from the study's public registry record.
Tzung-Dau Wang, MD, PhD · 886-972651070 · tdwang@ntu.edu.tw
Ya-Chun Chen, BS · 886-2-23123456 · yachun0411@gmai.com
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| National Taiwan University Hospital | Taipei, Taiwan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06676553