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Study identifier: NCT06676449 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

TDLN-sparing RT Plus Immunotherapy and Chemotherapy in Locally Advanced ESCC

Condition: Esophageal Carcinoma · Radiotherapy · Immunotherapy  ·  Sponsor: Fudan University

PhasePhase 3
Planned participants432
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if immunotherapy in combination with tumor draining lymph nodes-sparing radiotherapy (TDLN-sparing RT) and chemotherapy works to treat locally advanced esophageal squamous cell cancer in adults. Researchers will compare immunotherapy in combination with TDLN-sparing RT and chemotherapy to TDLN-sparing RT and chemotherapy to see if immunotherapy works more effectively when using TDLN-sparing RT to treat locally advanced esophageal squamous cell cancer Participants will: TDLN-sparing RT for esophageal cancer 50.4Gy/28Fx Paclitaxel plus cisplatin every 3 weeks for 4 cycles PD-1 inhibitors or observation every 3 weeks for 1 year

This description comes directly from the study's public registry record.

Talk to the study team

Dashan Zhao  ·  +862164175590  ·  kuaile_z@sina.com

Always discuss trial participation with your own doctor first.

Locations (1)

Fudan University Shanghai Cancer CenterShanghai, Shanghai Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06676449