Condition: IgA Nephropathy · Renal Insufficiency, Chronic · IgA Vasculitis · Sponsor: Christian Medical College, Vellore, India
Global Burden of Diseases ranks chronic kidney disease (CKD) as the 12th leading cause of death, with an estimated 20% increase from 2010 to 2019. India is the most populous country in South Asia, with one-fourth of the global population. CKD prevalence has reached epidemic proportions in South Asia, with 1 in 7 adults affected by it. Glomerular diseases are the most common cause of CKD after diabetes and hypertension. IgAN is the most common primary glomerular disease in adults. In the Caucasian and East Asian populations, IgAN results in end-stage kidney disease (ESKD) in 15-20% of patients within 15-20 years after the first clinical presentation. Our first prospective observational (GRACE-IgANI) cohort since 2015 showed that South Asians have severe and progressive IgAN, with 39% having a rapid fall in eGFR, 25% having non-remission of proteinuria, and 36% reaching an adverse kidney outcome at three years. Our group has shown that South Asian ethnicity is associated with a severe phenotype, rapid progression, and significant ethnic differences in biomarkers. Over the last few years, newer anti-proteinuric agents and immunomodulatory drugs have either been approved by the FDA or are in the late phases of clinical trials for various proteinuric kidney diseases. The results of the STOP-IgAN and the recent TESTING trial have shown that the short-term beneficial effects of steroids on proteinuria and eGFR slope at six months wane over time, and there is a need for effective l…
This description comes directly from the study's public registry record.
Suceena Alexander, DM, PhD. · +91-417- · suceena@cmcvellore.ac.in
Selvin Sundar Raj, MD, DM · +91-417- · selvinsr@cmcvellore.ac.in
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| Kasturba Medical College, Manipal | Udupi, Karnataka, India | Not Yet Recruiting |
| KEM Hospital | Mumbai, Maharashtra, India | Not Yet Recruiting |
| Safdarjung Hospital, Ansari Nagar East | Delhi, New Delhi, India | Not Yet Recruiting |
| AIIMS Bhubaneswar | Bhubaneswar, Odisha, India | Not Yet Recruiting |
| JIPMER, JIPMER Campus | Puducherry, Puducherry, India | Not Yet Recruiting |
| Madras Medical College | Chennai, Tamil Nadu, India | Not Yet Recruiting |
| Christian Medical College Vellore | Vellore, Tamil Nadu, India | Recruiting |
| Nizams Institute of Medical Sciences | Hyderabad, Telangana, India | Not Yet Recruiting |
| Osmania Medical College | Hyderabad, Telangana, India | Not Yet Recruiting |
| Sanjay Gandhi Post Graduate Institute of Medical Sciences | Lucknow, Uttar Pradesh, India | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06676384