Condition: Decompensated Liver Cirrhosis · Primary Biliary Cholangitis · Primary Sclerosing Cholangitis · Sponsor: Assistance Publique - Hôpitaux de Paris
Intro: The present clinical research protocol is part of the LEOPARD European project (Grant n° 101080964 Horizon Europe) which aims to design and validate new predictive models of mortality among liver transplantation (LT) candidates. MELD based-liver graft allocation systems have become increasingly inaccurate over the last decade to predict mortality/dropout of liver transplantation (LT) candidates on the waitlist (WL). Wide disparities in mortality/dropout on the WL also exist across European countries, ranging from 5 to 30% according to transplantation indications and countries. In this setting, the European Commission- Horizon Europe funded-LEOPARD project intends to design new, 2nd generation, AI-machine learning-based predictive models of delisting in LT candidates, to better serve on time patients with the highest risk of dropout on the WL and to improve equity of access to LT across Europe. Hypothesis/Objective: The scientific justification of the LEOPARD TVDCS is therefore to collect a large set of data in liver transplantation candidates listed in Europe a) to design and b) to validate LEOPARD 2nd generation AI-based predictive models of mortality/dropout The primary objective is to develop new predictive models of mortality/drop out on the waitlist in patients with decompensated cirrhosis, or other end-stage chronic liver diseases, and in patients listed for Hepato-cellular carcinoma (HCC). Method: Longitudinal multicenter prospective health care data collec…
This description comes directly from the study's public registry record.
Christophe DUVOUX, MD-PHD · 01 49 81 23 25 · christophe.duvoux@aphp.fr
Nihel BERREBEH, Project Manager · 01 40 27 46 20 · nihel.berrebeh@aphp.fr
Always discuss trial participation with your own doctor first.
| Universitätsklinik für Allgemeinchirurgie, Klinische Abteilung für Transplantation | Vienna, Austria | Recruiting |
| Department of Gastroenterology and Hepatology Universitair Ziekenhuis Gent | Ghent, Belgium | Not Yet Recruiting |
| CHU Jean Minjoz Besançon, Department of Hepatology | Besançon, France | Recruiting |
| CHU Trousseau Tours, Department of Hepatology | Chambray-lès-Tours, France | Recruiting |
| CHU Beaujon, Department of Hepatology | Clichy, France | Recruiting |
| Hospital Henri Mondor, Department of Hepatology | Créteil, France | Recruiting |
| CHU Dijon, Department of Hepatology | Dijon, France | Recruiting |
| CHRU Huriez Lille, Department of Hepatology | Lille, France | Recruiting |
| CHU Lyon Croix Rousse, Department of Hepatology | Lyon, France | Not Yet Recruiting |
| CHU La Timone AP-HM, Department of Hepatology | Marseille, France | Not Yet Recruiting |
| CHRU Montpellier Saint Eloi, Department of Hepatology | Montpellier, France | Recruiting |
| CHU L'Archet Nice, Department of Hepatology | Nice, France | Recruiting |
+ 10 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06675604