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Study identifier: NCT06672939 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

Condition: Obesity · Overweight  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants150
Who can joinAll sexes, 12 Years to 17 Years
Healthy volunteersNo

About this study

The main purpose of this study, performed under Master Protocol J4M-MC-PWMP (NCT06672549), is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the study will last about 18 months. Participants who have completed the primary PW01 study (including the 4-week safety follow-up period) will have the opportunity to receive an additional 156 weeks of treatment with orforglipron as well as continuing the lifestyle intervention.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (38)

Carey Chronis MD Pediatric, Infant and Adolescent MedicineVentura, California, United StatesActive Not Recruiting
Stamford Therapeutics ConsortiumStamford, Connecticut, United StatesActive Not Recruiting
Children's Healthcare of Atlanta - Center for Advanced PediatricsAtlanta, Georgia, United StatesActive Not Recruiting
Ann & Robert H. Lurie Children's Hospital of ChicagoChicago, Illinois, United StatesActive Not Recruiting
Velocity Clinical ResearchLafayette, Louisiana, United StatesActive Not Recruiting
MedPharmics, LLCGulfport, Mississippi, United StatesRecruiting
Sundance Clinical ResearchSt Louis, Missouri, United StatesActive Not Recruiting
Lucas Research, Inc.Morehead City, North Carolina, United StatesActive Not Recruiting
Childrens Hospital of PittsburghPittsburgh, Pennsylvania, United StatesActive Not Recruiting
Vanderbilt Health One Hundred OaksNashville, Tennessee, United StatesActive Not Recruiting
Dynamed Clinical Research, LP d/b/a DM Clinical ResearchHouston, Texas, United StatesActive Not Recruiting
La Providence Pediatrics Clinic - Chemidox Clinical TrialsHouston, Texas, United StatesActive Not Recruiting

+ 26 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06672939