Condition: Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder · EBV-Related Post-Transplant Lymphoproliferative Disorder · Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder · Sponsor: Timothy Voorhees
This phase Ib trial tests the safety and effectiveness of epcoritamab in treating patients with post-transplant lymphoproliferative disorder (PTLD) that has come back after a period of improvement (relapsed) or has not responded to previous treatment (refractory). Epcoritamab, a bispecific antibody, binds to a protein called CD3, which is found on T cells (a type of white blood cell). It also binds to a protein called CD20, which is found on B cells (another type of white blood cell) and some lymphoma cells. This may help the immune system kill cancer cells. Giving epcoritamab may be safe and effective in treating patients with relapsed or refractory B-cell PTLD.
This description comes directly from the study's public registry record.
The Ohio State University Comprehensive Cancer Center · 800-293-5066 · OSUCCCClinicaltrials@osumc.edu
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| Washington University | St Louis, Missouri, United States | Recruiting |
| Ohio State University Comprehensive Cancer Center | Columbus, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06672705